Flt3 itd positive意思

"FLT3 ITD positive" is a term used in the field of oncology, particularly in the context of acute myeloid leukemia (AML). It refers to a genetic mutation in the FLT3 gene, which is a receptor tyrosine kinase gene. The mutation involves the presence of an internal tandem duplication (ITD) within the FLT3 gene.

The FLT3-ITD mutation leads to the production of a constitutively active FLT3 receptor, which is continuously active and signals even in the absence of its normal ligand. This abnormal signaling can lead to uncontrolled cell growth and the development of leukemia.

AML patients who are FLT3-ITD positive have a poorer prognosis compared to those without the mutation, as the mutation is associated with a higher risk of relapse and a lower rate of disease-free survival. The presence of FLT3-ITD is also a factor in determining treatment options, as some targeted therapies, such as FLT3 inhibitors, are designed to block the activity of the mutated FLT3 receptor and may be used in the treatment of FLT3-ITD positive AML.