Tolerization意思

"Tolerization" is a term used in the context of immunology, specifically in the field of transplantation biology and autoimmune diseases. It refers to the process of inducing tolerance in the immune system to prevent it from attacking a specific tissue, organ, or self-antigen.

In the context of transplantation, tolerization aims to prevent the immune system from rejecting a transplanted organ. This can be achieved by various methods, such as administering antibodies that deplete immune cells, using drugs that suppress the immune response, or manipulating the recipient's immune system to accept the transplanted organ as "self."

In the context of autoimmune diseases, tolerization aims to stop the immune system from attacking the body's own tissues. This can be done by presenting the immune system with modified self-antigens that do not cause inflammation but can induce tolerance.

Tolerization is a complex process that involves various mechanisms, including the induction of regulatory T cells (Tregs), which can suppress the activity of other immune cells. Tolerization is a promising area of research in the treatment of transplant rejection and autoimmune diseases, as it offers the potential for long-term immune suppression without the side effects of conventional immunosuppressive drugs.